发明授权
- 专利标题： Phenylalanine derivatives as endothelin antagonists
- 专利标题（中）： 苯丙氨酸衍生物作为内皮素拮抗剂
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申请号： US369209申请日： 1995-01-05
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公开(公告)号： US5658943A公开(公告)日： 1997-08-19
- 发明人: Kent Alan Berryman , Xue-Min Cheng , Annette Marian Doherty , Jeremy John Edmunds , Sylvester Klutchko
- 申请人： Kent Alan Berryman , Xue-Min Cheng , Annette Marian Doherty , Jeremy John Edmunds , Sylvester Klutchko
- 申请人地址： NJ Morris Plains
- 专利权人： Warner-Lambert Company
- 当前专利权人： Warner-Lambert Company
- 当前专利权人地址： NJ Morris Plains
- 主分类号： C07C229/36
- IPC分类号： C07C229/36 ; C07C233/51 ; C07C275/28 ; C07C323/59 ; C07D317/54 ; C07D317/60 ; C07C229/30 ; C07C317/60
摘要：
Novel antagonists of endothelin are described, as well as novel intermediates used in their preparation, methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, essential, renovascular, malignant and pulmonary hypertension, cerebral infarction, myocardial ischemia, cerebral ischemia, congestire heart failure and subarachnoid hemorrhage.
公开/授权文献
- US4924049A Bacon Box 公开/授权日：1990-05-08
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