发明授权
- 专利标题： Promotors that regulate the expression of genes involved in cell death
- 专利标题（中）： 调节细胞死亡基因表达的启动子
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申请号： US330535申请日： 1994-10-27
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公开(公告)号： US5659024A公开(公告)日： 1997-08-19
- 发明人: John C. Reed , Toshiyuki Miyashita , Masayoshi Harigai , Motoi Hanada
- 申请人： John C. Reed , Toshiyuki Miyashita , Masayoshi Harigai , Motoi Hanada
- 申请人地址： CA La Jolla
- 专利权人： The Burnham Institute
- 当前专利权人： The Burnham Institute
- 当前专利权人地址： CA La Jolla
- 主分类号： C07K14/47
- IPC分类号： C07K14/47 ; C07K14/82 ; C12Q1/68 ; C07H21/04
摘要：
The present invention provides regulatory elements that are linked to genes involved in cell death. For example, the present invention provides a p53-RE.sup.D, which is involved in p53-mediated down-regulation of the bcl-2 gene, and the bax promotor, which contains a p53-RE.sup.U that is involved in p53-mediated up-regulation of the bax gene. The invention also provides screening assays for identifying agents such as drugs that effectively modulate expression of a gene that is involved in cell death. In addition, the invention provides methods for modulating the level of apoptosis in a cell.
公开/授权文献
- US4467206A Method and apparatus for the irradiation of fluids 公开/授权日：1984-08-21
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