发明授权
- 专利标题: Tetrahydrofuran antifungals
- 专利标题(中): 四氢呋喃抗真菌剂
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申请号: US460752申请日: 1995-06-02
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公开(公告)号: US5661151A公开(公告)日: 1997-08-26
- 发明人: Anil K. Saksena , Viyyoor M. Girijavallabhan , Raymond G. Lovey , Russell E. Pike , Haiyan Wang , Yi-Tsung Liu , Ashit K. Ganguly , Frank Bennett
- 申请人: Anil K. Saksena , Viyyoor M. Girijavallabhan , Raymond G. Lovey , Russell E. Pike , Haiyan Wang , Yi-Tsung Liu , Ashit K. Ganguly , Frank Bennett
- 申请人地址: NJ Kenilworth
- 专利权人: Schering Corporation
- 当前专利权人: Schering Corporation
- 当前专利权人地址: NJ Kenilworth
- 主分类号: C07D405/14
- IPC分类号: C07D405/14 ; A61K31/41 ; A61K31/495 ; A61K31/675 ; A61P31/00 ; A61P31/10 ; C07D521/00 ; C07F9/6558 ; C07D413/14 ; C07F9/6518
摘要:
A compound represented by the formula I ##STR1## wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R.sub.1 is a straight or branched chain (C.sub.3 to C.sub.8) alkyl group substituted by one or two hydroxy moieties, an ether or ester thereof (e.g., a polyether ester amino acid ester or phosphate ester) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.