发明授权
- 专利标题： Human interleukin-8 analogs
- 专利标题（中）： 人白细胞介素-8类似物
-
申请号： US244702申请日： 1994-09-27
-
公开(公告)号： US5665346A公开(公告)日： 1997-09-09
- 发明人: Ian Clark-Lewis , Bernhard Moser
- 申请人： Ian Clark-Lewis , Bernhard Moser
- 申请人地址： AZ Tucson
- 专利权人： Research Corporation Technologies, Inc.
- 当前专利权人： Research Corporation Technologies, Inc.
- 当前专利权人地址： AZ Tucson
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K14/54 ; A61K38/20 ; A61K38/19 ; C07K14/52
摘要：
The present invention provides human interleukin-8 (IL-8) analogs that are modified in the Glu4 Leu5 Arg6 region, and have a core structure corresponding to the IL-8 (7-51) sequence are provided. These neutrophil binding analogs display altered IL-8 activities that can be exploited for therapeutic and other purposes. Such antagonists include those in which, for example, the Leu5 and/or Arg6 residues are replaced, and in which the Glu4 and/or Leu5 residues are deleted. Also provided are biologically active human interleukin-8 (IL-8) analogs comprising a core sequence that includes IL-8 (1-51), IL-8 (3-51) or IL-8 (4-51). The invention also provides pharmaceutical compositions containing the aforementioned analogs.
公开/授权文献
信息查询
IPC分类:
