发明授权
US5668150A Non-symmetrical bis-heteroarylmethoxyphenylalkyl carboxylates as
inhibitors of leukotriene biosynthesis
失效
非对称双杂芳基甲氧基苯基烷基羧酸盐作为白三烯生物合成的抑制剂
- 专利标题: Non-symmetrical bis-heteroarylmethoxyphenylalkyl carboxylates as inhibitors of leukotriene biosynthesis
- 专利标题(中): 非对称双杂芳基甲氧基苯基烷基羧酸盐作为白三烯生物合成的抑制剂
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申请号: US686841申请日: 1996-07-26
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公开(公告)号: US5668150A公开(公告)日: 1997-09-16
- 发明人: Clint D.W. Brooks , Teodozyj Kolasa , David E. Gunn
- 申请人: Clint D.W. Brooks , Teodozyj Kolasa , David E. Gunn
- 申请人地址: IL Abbott Park
- 专利权人: Abbott Laboratories
- 当前专利权人: Abbott Laboratories
- 当前专利权人地址: IL Abbott Park
- 主分类号: A61K31/47
- IPC分类号: A61K31/47 ; A61K31/4709 ; A61P29/00 ; A61P37/08 ; A61P43/00 ; C07D215/14 ; C07D401/12 ; C07D413/12 ; C07D417/12 ; A61K31/475 ; C07D215/18
摘要:
Compounds having the formula ##STR1## wherein W and Y are independently selected from optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, optionally substituted benzimidazolyl, optionally substituted quinoxalyl, and optionally substituted naphthyl with the proviso that W and Y are not simultaneously the same substituent; R.sup.1 and R.sup.2 are independently hydrogen, alkyl, haloalkyl, alkoxy, or halogen; R.sup.3 is hydrogen or alkyl; X is absent or is alkylene, alkenylene, or alkynylene; and M is selected from (a) a pharmaceutically acceptable metabolically cleavable group, (b) --OR.sup.4 wherein R.sup.4 is hydrogen or alkyl; and (c) --NR.sup.5 R.sup.6 wherein R.sup.5 and R.sup.6 are independently selected from hydrogen, alkyl, hydroxy and alkoxy are disclosed. These compounds inhibit leukotriene biosynthesis and are useful in the treatment of allergic and inflammatory disease states.
公开/授权文献
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