发明授权
- 专利标题: Antiallergic imidazoazepines
- 专利标题(中): 抗过敏咪唑并吖嗪
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申请号: US557131申请日: 1995-12-13
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公开(公告)号: US5674866A公开(公告)日: 1997-10-07
- 发明人: Frans Eduard Janssens , Joseph Elisabeth Leenaerts
- 申请人: Frans Eduard Janssens , Joseph Elisabeth Leenaerts
- 申请人地址: BEX Beerse
- 专利权人: Janssen Pharmaceutica N.V.
- 当前专利权人: Janssen Pharmaceutica N.V.
- 当前专利权人地址: BEX Beerse
- 优先权: EPX93202154 19930713
- 主分类号: A61K31/4184
- IPC分类号: A61K31/4184 ; A61K31/55 ; A61P11/06 ; A61P17/00 ; A61P27/14 ; A61P27/16 ; A61P37/08 ; C07D401/04 ; C07D401/06 ; C07D401/14 ; C07D405/14 ; C07D409/14 ; C07D471/04 ; C07D487/04 ; C07D487/14 ; C07D491/14 ; C07D491/147 ; C07D495/14 ; C07D513/04 ; C07D519/00
摘要:
The present invention is concerned with novel imidazoazepines of formula ##STR1## the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the dotted lines independently represents an optional bond; --A--B-- is a radical of formula --X--CH.dbd.CH-- (a-1); --CH.dbd.CH--X-- (a-2); or --CH.dbd.CH-- CH.dbd.CH-- (a-3); X represents O, S or NR.sup.1 ; R.sup.1 represents hydrogen or C.sub.1-6 alkyl; -----Y is a radical of formula .dbd.O (b-1); --OH (b-2); or .dbd.N--OH (b-3); and L represents hydrogen, C.sub.1-4 alkylcarbonyl, C.sub.1-4 alkyloxycarbonyl, phenylcarbonyl, C.sub.1-6 alkyl or C.sub.1-6 alkyl substituted with C.sub.1-4 alkyloxycarbonyl, hydroxycarbonyl, aryl, aryloxy or a radical of formula ##STR2## --D--Z-- is --S--CH.dbd.CH--, --S--CH.sub.2 --CH.sub.2 --, --S--CH.sub.2 --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 --; and aryl is phenyl or phenyl substituted with halo, hydroxy or C.sub.1-4 alkyloxy. Compositions comprising said compounds, processes for preparing the same and the use of these compounds for treating allergic diseases.
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