发明授权
- 专利标题： Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
- 专利标题（中）： 能抑制表皮生长因子受体家族酪氨酸激酶的三环化合物
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申请号： US358352申请日： 1994-12-23
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公开(公告)号： US5679683A公开(公告)日： 1997-10-21
- 发明人: Alexander James Bridges , William Alexander Denny , David Fry , Alan Kraker , Robert Frederick Meyer , Gordon William Rewcastle , Andrew Mark Thompson , Howard Daniel Hollis Showalter
- 申请人： Alexander James Bridges , William Alexander Denny , David Fry , Alan Kraker , Robert Frederick Meyer , Gordon William Rewcastle , Andrew Mark Thompson , Howard Daniel Hollis Showalter
- 申请人地址： NJ Morris Plains
- 专利权人： Warner-Lambert Company
- 当前专利权人： Warner-Lambert Company
- 当前专利权人地址： NJ Morris Plains
- 主分类号： A61K31/519
- IPC分类号： A61K31/519 ; A61P15/00 ; A61P35/00 ; C07D213/00 ; C07D239/00 ; C07D239/70 ; C07D333/00 ; C07D471/04 ; C07D471/14 ; C07D473/34 ; C07D487/04 ; C07D491/04 ; C07D491/14 ; C07D495/04 ; C07D498/14 ; C07D513/04 ; C07D513/14 ; A61K31/505 ; C07D487/00
摘要：
Novel 4-substituted amino benzothieno�3,2-d!pyrimidine and 4-substituted amino�2,3-d!pyrimidine inhibitors of epidermal growth factor receptor family of tyrosine kinases are described, as well as pharmaceutical compositions of the same, which are useful in treating proliferative diseases such as cancer, synovial pannus invasion in arthritis, psoriasis, vascular restenosis and angiogenesis and additionally useful in the treatment of pancreatitis and kidney disease as well as a contraceptive agent.
公开/授权文献
- US4938154A Security closure 公开/授权日：1990-07-03
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