发明授权
- 专利标题： Synthetic inhibitors of mammalian collagenase
- 专利标题（中）： 哺乳动物胶原酶的合成抑制剂
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申请号： US468491申请日： 1995-06-06
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公开(公告)号： US5686422A公开(公告)日： 1997-11-11
- 发明人: Robert D. Gray , Arno F. Spatola , Robert B. Miller , Frank R. Burns , Christopher Paterson
- 申请人： Robert D. Gray , Arno F. Spatola , Robert B. Miller , Frank R. Burns , Christopher Paterson
- 申请人地址： AZ Tucson
- 专利权人： Research Corporation Technologies, Inc.
- 当前专利权人： Research Corporation Technologies, Inc.
- 当前专利权人地址： AZ Tucson
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K5/065 ; C07K5/068 ; C07K5/087 ; A61K37/00
摘要：
The present invention relates to compounds of the formula: R.sub.1 SCH(R.sub.2)CH(R.sub.3)CO-AA.sub.1 �AA.sub.2 !.sub.m �AA.sub.3 !.sub.n --X or HSCH.sub.2 �CH.sub.2 CH(CH.sub.3).sub.2 !CO--Nal--NH.sub.2 wherein Nal is L-3-(2-naphthyl)alanine; m is the integer 0 or 1; n is an integer from 0-2; AA.sub.1 is a non-polar hydrophobic aromatic amino acid; AA.sub.2 is alanine, glycine, leucine, isoleucine or phenylalanine; AA.sub.3 is one of the twenty naturally occurring amino acids, preferably glutamine or arginine; R.sub.1 is hydrogen, alkyl having from 1-10 carbon atoms, alkanoyl having from 2-10 carbon atoms, or aroyl having from 7-10 carbon atoms; R.sub.2 is hydrogen or alkyl having from 1-6 carbon atoms; R.sub.3 is hydrogen, alkyl having from 2-10 carbon atoms, cycloalkyl having from 3-6 carbon atoms, aryl or arylalkyl, wherein aryl moieties have from 6-10 carbon atoms; X is NH.sub.2, OH, OCH.sub.3 or OCH.sub.2 CH.sub.3 ; and salts thereof.
公开/授权文献
- US4525347A Antiinflammatory analgesic gelled ointment 公开/授权日：1985-06-25
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