发明授权
US5686471A Dihydrobenzofuran and related compounds useful as anti-inflammatory
agents
失效
二氢苯并呋喃及相关化合物可用作抗炎剂
- 专利标题: Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
- 专利标题(中): 二氢苯并呋喃及相关化合物可用作抗炎剂
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申请号: US595120申请日: 1996-02-01
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公开(公告)号: US5686471A公开(公告)日: 1997-11-11
- 发明人: Zhuoliang Chen , John Michael Janusz
- 申请人: Zhuoliang Chen , John Michael Janusz
- 申请人地址: OH Cincinnati
- 专利权人: The Procter & Gamble Company
- 当前专利权人: The Procter & Gamble Company
- 当前专利权人地址: OH Cincinnati
- 主分类号: A61K31/38
- IPC分类号: A61K31/38 ; A61K31/381 ; A61K31/415 ; A61K31/4155 ; A61K31/44 ; A61K31/443 ; A61K31/4433 ; A61P19/02 ; A61P25/04 ; A61P29/00 ; C07D333/54 ; C07D405/06 ; C07D409/06 ; A61K31/34 ; C07D407/06
摘要:
A compound having the structure: ##STR1## wherein (a) n is from about 1 to about 3; (b) X is selected from the group consisiting of O, S, SO, or SO.sub.2 ; (c) Y is independently hydrogen or straight, branched or cyclic alkyl or aralkyl having from 1 to about 3 carbon atoms; or the Y's are bonded together to form an alkanyl ring having from 3 to about 7 atoms; (d) Z is hydrogen or straight, branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen; (e) R.sub.1 and R.sub.2 are each independently hydrogen or straight, branched or cyclic alkyl, unsubstituted or substituted, carboxyl, carboxamido, alkoxycarbonyl or alkylcarbonyl; and (f) Het is a heteroaryl group comprising one or more rings containing from about 5 to about 8 atoms in the rings and wherein at least one ring has at least one heteroatom selected from O, N, or S, pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.
公开/授权文献
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