发明授权
US5691307A O.sup.6 -substituted guanine compositions and methods for depleting O.sup.6
失效
O6取代的鸟嘌呤组合物和用于消耗O6-烷基鸟嘌呤-DNA烷基转移酶的方法
- 专利标题： O.sup.6 -substituted guanine compositions and methods for depleting O.sup.6
- 专利标题（中）： O6取代的鸟嘌呤组合物和用于消耗O6-烷基鸟嘌呤-DNA烷基转移酶的方法
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申请号： US255190申请日： 1994-06-07
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公开(公告)号： US5691307A公开(公告)日： 1997-11-25
- 发明人: Robert C. Moschel , M. Eileen Dolan , Anthony E. Pegg , Mark G. McDougall , Mi-Young Chae
- 申请人： Robert C. Moschel , M. Eileen Dolan , Anthony E. Pegg , Mark G. McDougall , Mi-Young Chae
- 申请人地址： DC Washington PA University Park IL Chicago
- 专利权人： The United States of America as represented by the Department of Health and Human Services,The Penn State Research Foundation,Arch Development Corporation
- 当前专利权人： The United States of America as represented by the Department of Health and Human Services,The Penn State Research Foundation,Arch Development Corporation
- 当前专利权人地址： DC Washington PA University Park IL Chicago
- 主分类号： C07H19/16
- IPC分类号： C07H19/16 ; A61K31/54 ; A61K31/52 ; A61K31/535 ; A61K31/70 ; C07D403/02 ; C07D403/12 ; C07D473/18
摘要：
Novel O.sup.6 -substituted guanine compounds and pharmaceutical compositions thereof are useful for effectively reducing O.sup.6 -alkylguanine-DNA alkyltransferase (AGT). The novel compounds are useful for treating tumors and when used with anti-neoplastic alkylating agents enhance the chemotherapeutic treatment of tumor cells in a host.
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