发明授权
- 专利标题： 6-position modified decapeptide LHRH antagonists
- 专利标题（中）： 6位修饰的十肽LHRH拮抗剂
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申请号： US446809申请日： 1995-06-01
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公开(公告)号： US5698522A公开(公告)日： 1997-12-16
- 发明人: Fortuna Haviv , Timothy D. Fitzpatrick , Rolf E. Swenson , Charles J. Nichols , Nicholas A. Mort , Jonathan Greer
- 申请人： Fortuna Haviv , Timothy D. Fitzpatrick , Rolf E. Swenson , Charles J. Nichols , Nicholas A. Mort , Jonathan Greer
- 申请人地址： IL Abbott Park
- 专利权人： Abbott Laboratories
- 当前专利权人： Abbott Laboratories
- 当前专利权人地址： IL Abbott Park
- 主分类号： A61K38/04
- IPC分类号： A61K38/04 ; A61K38/00 ; A61P5/00 ; C07K7/23 ; A61K38/09
摘要：
The present invention provides a class of decapeptide compounds which are potent antagonists of LHRH activity and which have the structure A.sup.1 -D.sup.2 -E.sup.3 -G.sup.4 -J.sup.5 -L.sup.6 -M.sup.7 -Q.sup.8 -R.sup.9 -T.sup.10. The compounds of the percent invention are characterized by having an .OMEGA.-amino-functionalized side chain on the D-aminoacyl residue at position 6. The .OMEGA.-amino group of this side chain is further derivatized by the attachment of an extending group which likewise has a terminal amino group which is capped by an acyl group.
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