发明授权
US5698570A Quinoline carboxylic acid derivatives having
7-(4-amino-methyl-3-oxime)pyrrolidine substituent and processes for
preparing thereof
失效
具有7-（4-氨基 - 甲基-3-肟）吡咯烷取代基的喹啉羧酸衍生物及其制备方法
- 专利标题： Quinoline carboxylic acid derivatives having 7-(4-amino-methyl-3-oxime)pyrrolidine substituent and processes for preparing thereof
- 专利标题（中）： 具有7-（4-氨基 - 甲基-3-肟）吡咯烷取代基的喹啉羧酸衍生物及其制备方法
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申请号： US791749申请日： 1997-01-30
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公开(公告)号： US5698570A公开(公告)日： 1997-12-16
- 发明人: Chang Yong Hong , Young Kwan Kim , Jay Hyok Chang , Se Ho Kim , Hoon Choi , Do Hyun Nam , Jin Hwan Kwak , Yi Na Jeong , Jeong In Oh , Mu Yong Kim
- 申请人： Chang Yong Hong , Young Kwan Kim , Jay Hyok Chang , Se Ho Kim , Hoon Choi , Do Hyun Nam , Jin Hwan Kwak , Yi Na Jeong , Jeong In Oh , Mu Yong Kim
- 申请人地址： KRX Seoul
- 专利权人： LG Chemical Ltd.
- 当前专利权人： LG Chemical Ltd.
- 当前专利权人地址： KRX Seoul
- 优先权： KRX94-13604 19940616; KRX94-39915 19941230; KRX94-39930 19941230
- 主分类号： A61K31/435
- IPC分类号： A61K31/435 ; A61K31/47 ; A61P31/04 ; C07D401/04 ; C07D401/14 ; C07D405/14 ; C07D413/14 ; C07D417/14 ; C07D471/04 ; C07D401/02
摘要：
The present invention relates to a novel quinolone compound having an excellent antibacterial activity. More specifically, the present invention relates to a novel quinoline(naphthyridine)carboxylic acid derivative represented by the following formula (I), which has an 4-aminomethyl-3-oximepyrrolidine substituent on 7-position of the quinolone nucleus and shows a superior antibacterial activity in contrast to the known quinolone antibactrial agents having a weak activity against gram-positive bacterial strains and also has a broad antibacterial spectrum and a highly improved pharmacokinetic property: ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and Q are defined as described in the specification.
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