发明授权
- 专利标题： Piperazine derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them
- 专利标题（中）： 哌嗪衍生物，含有这些化合物的药物组合物，其用途和制备方法
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申请号： US572256申请日： 1995-12-13
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公开(公告)号： US5700801A公开(公告)日： 1997-12-23
- 发明人: Helmut Pieper , Volkhard Austel , Frank Himmelsbach , Gunter Linz , Brian Guth , Johannes Weisenberger
- 申请人： Helmut Pieper , Volkhard Austel , Frank Himmelsbach , Gunter Linz , Brian Guth , Johannes Weisenberger
- 申请人地址： DEX Biberach An Der Riss
- 专利权人： Karl Thomae, GmbH
- 当前专利权人： Karl Thomae, GmbH
- 当前专利权人地址： DEX Biberach An Der Riss
- 优先权： DEX4446300.6 19941223; DEX19533224.5 19950908
- 主分类号： C07D295/18
- IPC分类号： C07D295/18 ; A61K31/495 ; A61P7/02 ; A61P29/00 ; A61P35/00 ; A61P43/00 ; C07D211/34 ; C07D211/58 ; C07D213/74 ; C07D213/78 ; C07D401/12 ; C07D211/18
摘要：
Piperazine derivatives useful in the treatment or prevention of inflammation, bone degradation, thrombosis and tumor metastasis. Exemplary species are: (a) �4-trans-�3-�4-(4-Pyridyl)-piperazin-1-yl!propionyl!amino!-cyclohexanecarboxylic acid, (b) 3-�4-trans-�4-(4-Pyridyl)-piperazin-1-yl!carbonylamino!-cyclohexylpropionic acid, (c) 3-�4-trans-�4-(4-Pyridyl)-piperazin-1-yl!malonylamino!cyclohexylcarboxylic acid, (d) Methyl �4-trans-�3-�4-(4-pyridyl)-piperazin-1-yl!-propionyl!-amino!cyclohexane carboxylate, (e) Methyl 3-�4-trans-�4-(4-pyridyl)-piperazin-1-yl!-carbonylamino!cyclohexyl propionate, (f) Methyl �4-trans-�4-(4-pyridyl)-piperazin-1-yl!-malonylamino!-cyclohexyl carboxylate, (g) Cyclohexyl �4-trans-��4-(4-pyridyl)-piperazin-1-yl!-acetyl!-amino!-cyclohexane carboxylate, and (h) Isobutyl �4-trans-��4-(4-pyridyl)-piperazin-1-yl!-acetyl!-amino!-cyclohexane carboxylate.
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