发明授权
US5703129A 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of
.beta.-amyloid protein production
失效
5-氨基-6-环己基-4-羟基 - 己酰胺衍生物作为β-淀粉样蛋白生产的抑制剂
- 专利标题： 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of .beta.-amyloid protein production
- 专利标题（中）： 5-氨基-6-环己基-4-羟基 - 己酰胺衍生物作为β-淀粉样蛋白生产的抑制剂
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申请号： US723488申请日： 1996-09-30
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公开(公告)号： US5703129A公开(公告)日： 1997-12-30
- 发明人: Kevin Felsenstein , David W. Smith , Michael A. Poss , Prasad Chaturvedula , Charles P. Sloan
- 申请人： Kevin Felsenstein , David W. Smith , Michael A. Poss , Prasad Chaturvedula , Charles P. Sloan
- 申请人地址： NY New York
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： NY New York
- 主分类号： C07C237/14
- IPC分类号： C07C237/14 ; C07C323/41 ; C07D307/33 ; A61K31/17
摘要：
A series of 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives of Formula I have been synthesized. ##STR1## As inhibitors of the production of .beta.-amyloid protein from .beta.-amyloid precursor protein, these compounds are expected to be effective in treating patients suffering from or susceptible to conditions or disorders linked to brain accumulation of .beta.-amyloid protein; e.g., Alzheimer's Disease and Down's Syndrome.
公开/授权文献
- US4050166A Recoil simulator 公开/授权日：1977-09-27
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