发明授权
US5721236A Tricyclic carbamate compounds useful for inhibition of G-protein
function and for treatment of proliferative diseases
失效
可用于抑制G蛋白功能和治疗增殖性疾病的三环氨基甲酸酯化合物
- 专利标题： Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
- 专利标题（中）： 可用于抑制G蛋白功能和治疗增殖性疾病的三环氨基甲酸酯化合物
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申请号： US410479申请日： 1995-03-24
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公开(公告)号： US5721236A公开(公告)日： 1998-02-24
- 发明人: W. Robert Bishop , Ronald J. Doll , Alan K. Mallams , F. George Njoroge , Joanne M. Petrin , John J. Piwinski , Ronald L. Wolin , Arthur G. Taveras , Stacy W. Remiszewski
- 申请人： W. Robert Bishop , Ronald J. Doll , Alan K. Mallams , F. George Njoroge , Joanne M. Petrin , John J. Piwinski , Ronald L. Wolin , Arthur G. Taveras , Stacy W. Remiszewski
- 申请人地址： NJ Kenilworth
- 专利权人： Schering Corporation
- 当前专利权人： Schering Corporation
- 当前专利权人地址： NJ Kenilworth
- 主分类号： A61K31/435
- IPC分类号： A61K31/435 ; A61K31/4375 ; A61K31/4545 ; A61K31/495 ; A61K31/496 ; A61P35/00 ; C07D221/06 ; C07D221/16 ; C07D401/04 ; C07D401/12 ; C07D401/14 ; C07D403/04
摘要：
A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a compound of Formula 1.0 ##STR1## Also disclosed are novel compounds of the formulas: ##STR2## Also disclosed are processes for making 3-substituted compounds of the Formulas 1.1, 1.2 and 1.3. Further disclosed are novel compounds which are intermediates in the processes for making the 3-substituted compounds of Formulas 1.1, 1.2, and 1.3.
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