发明授权
- 专利标题: Therapeutic phenoxyalkylazoles and phenoxyalkylazines
- 专利标题(中): 治疗性苯氧基烷基唑和苯氧基烷基嗪
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申请号: US693530申请日: 1996-08-02
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公开(公告)号: US5721261A公开(公告)日: 1998-02-24
- 发明人: David J. Aldous , Thomas R. Bailey , Guy Dominic Diana , Theodore J. Nitz , Gee-Hong Kuo
- 申请人: David J. Aldous , Thomas R. Bailey , Guy Dominic Diana , Theodore J. Nitz , Gee-Hong Kuo
- 申请人地址: NY New York
- 专利权人: Sanofi Pharmaceuticals, Inc.
- 当前专利权人: Sanofi Pharmaceuticals, Inc.
- 当前专利权人地址: NY New York
- 主分类号: C07D257/04
- IPC分类号: C07D257/04 ; C07D271/06 ; C07D277/24 ; C07D403/12 ; C07D405/12 ; C07D413/12 ; C07D417/12 ; C07D521/00 ; A61K31/41
摘要:
Compounds of the formula ##STR1## wherein Azo is alkyltetrazolyl or is chosen from the group consisting of oxadiazolyl, imidazolyl, pyrazolyl, triazolyl, oxazolyl, triazinyl, thiazolyl, isothiazolyl or any of these substituted with a member of the group consisting of alkyl, alkylthio, alkoxy, hydroxy, halo, cyano, nitro, hydroxyalkyl, alkoxyalkyl, alkoxycarbonyl, alkanoyl, fluoroalkyl or the N-oxide of any of the preceding; Y is an alkylene bridge of 3-9 carbon atoms; R.sub.1 and R.sub.2 are each individually chosen from hydrogen, halo, alkyl, alkenyl, amino, alkylthio, hydroxy, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, alkoxy, nitro, carboxy, alkoxycarbonyl, dialkylaminoalkyl, alkylaminoalkyl, aminoalkyl, difluoromethyl, trifluoromethyl or cyano; R.sub.3 is alkoxycarbonyl, alkyltetrazolyl, phenyl or a heterocycle chosen from benzoxazolyl, benzathiazolyl, thiadiazolyl, imidazolyl, dihydroimidazolyl, oxazolyl, thiazolyl, oxadiazolyl, pyrazolyl, isoxazolyl, isothiazolyl, furyl, triazolyl, tetrazolyl, thiophenyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl or substituted phenylor substituted heterocyclyl wherein the substitution is with alkyl, alkoxyalkyl, cycloalkyl, haloalkyl, hydroxyalkyl, alkoxy, hydroxy, furyl, thienyl or fluoroalkyl; the N-oxide thereof; or a pharmaceutically acceptable acid addition salt thereof is an effective antipicornaviral agents.
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