发明授权
US5731410A Peptide for blocking autoantibody-evoked activation of glutamate
receptor type 3 (GLUR3)
失效
用于阻断3型谷氨酸受体（GLUR3）的自身抗体诱发活化的肽
- 专利标题： Peptide for blocking autoantibody-evoked activation of glutamate receptor type 3 (GLUR3)
- 专利标题（中）： 用于阻断3型谷氨酸受体（GLUR3）的自身抗体诱发活化的肽
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申请号： US345527申请日： 1994-11-28
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公开(公告)号： US5731410A公开(公告)日： 1998-03-24
- 发明人: Scott W. Rogers , Lorise C. Gahring , Roy E. Twyman
- 申请人： Scott W. Rogers , Lorise C. Gahring , Roy E. Twyman
- 申请人地址： UT Salt Lake City
- 专利权人： University of Utah Research Foundation
- 当前专利权人： University of Utah Research Foundation
- 当前专利权人地址： UT Salt Lake City
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K14/705 ; C07K14/435 ; A61K38/16
摘要：
A peptide containing 24 amino acid residues that binds to anti-neuronal-glutamate-receptor autoantibodies associated with Rasmussen's encephalitis and that blocks activation of the GluR3 subunit is described. Methods of making the peptide and treating Rasmussen's encephalitis are also disclosed. Autoantibodies to other glutamate receptor subunits are associated with paraneoplastic neurodegenerative disease, amyotrophic lateral sclerosis, and neurodegenerative disease of unknown diagnosis. Methods of screening patients and of monitoring patients being treated for these disorders and syndromes are further described.
公开/授权文献
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