发明授权
US5733730A Telomere repeat binding factor and diagnostic and therapeutic use thereof
失效
端粒重复结合因子及其诊断和治疗用途
- 专利标题: Telomere repeat binding factor and diagnostic and therapeutic use thereof
- 专利标题(中): 端粒重复结合因子及其诊断和治疗用途
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申请号: US519103申请日: 1995-08-25
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公开(公告)号: US5733730A公开(公告)日: 1998-03-31
- 发明人: Titia De Lange
- 申请人: Titia De Lange
- 申请人地址: NY New York
- 专利权人: The Rockefeller University
- 当前专利权人: The Rockefeller University
- 当前专利权人地址: NY New York
- 主分类号: A61K38/00
- IPC分类号: A61K38/00 ; C07K14/47 ; C12N15/12 ; G01N33/68 ; C12Q1/68 ; G01N33/53
摘要:
The present invention relates to a novel nucleotide sequence encoding a telomeric protein which binds a repeat region of telomeric sequences, and to the protein encoded thereby. Also included within the invention are expression vectors for the production of the telomeric protein and host cells transformed with the nucleotide sequence. In addition, antibodies, probes and antagonists specific for the telomeric protein are contemplated. Methods of identifying antagonists of the telomeric protein, diagnostic methods of identifying the telomeric protein in a sample, and therapeutic uses of the telomeric protein, particularly in the treatment of aging and cancer, are also contemplated.
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