A method of making a cleaning scrubber comprising a step of preparing an elastic and reticulate tube, which is fitted over a locating set of a molding tool such that the tube is forced to expand and that the periphery of the tube is pleated. The expanded and pleated tube is then fastened with two resilient cords such that two fastened areas are opposite in location to each other and that two resilient cords form a ring located between the inner and the outer sides of the tube. Finally, the tube is removed from the molding foot and released to allow the periphery of the tube to expand along the cords serving as axes, so as to form a spherical cleaning scrubber.