发明授权
- 专利标题: Method of improving mass resolution in time-of-flight mass spectrometry
- 专利标题(中): 提高飞行时间质谱分辨率的方法
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申请号: US618843申请日: 1996-03-20
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公开(公告)号: US5742049A公开(公告)日: 1998-04-21
- 发明人: Armin Holle , Claus Koster , Jochen Franzen
- 申请人: Armin Holle , Claus Koster , Jochen Franzen
- 申请人地址: DEX Bremen
- 专利权人: Bruker-Franzen Analytik GmbH
- 当前专利权人: Bruker-Franzen Analytik GmbH
- 当前专利权人地址: DEX Bremen
- 优先权: DEX19547949.1 19951221
- 主分类号: H01J49/40
- IPC分类号: H01J49/40 ; B01D59/44 ; H01J49/00
摘要:
The invention relates to the use of a time-of-flight mass spectrometer to analyze substance molecules which are ionized by laser desorption, particularly by matrix-assisted laser desorption (MALDI). In detail it relates to the process for improving mass resolution by the known method of delayed acceleration (sometimes called delayed extraction) of the ions, and devices for the performance of this method. The invention consists of using an optical device with gridless apertures for the acceleration of the ions and refocusing the ion beam divergence due to the lens effect of the apertures, by means of a lens arrangement in the drift region of the time-of-flight spectrometer. For laser light pulses, illumination, and observation, there are further lateral holes in the electrodes of the optical device.
公开/授权文献
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