发明授权
- 专利标题: Fused phenol derivatives
- 专利标题(中): 稠油酚衍生物
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申请号: US635318申请日: 1996-04-19
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公开(公告)号: US5750544A公开(公告)日: 1998-05-12
- 发明人: Shuichi Ohuchida , Fumio Nambu , Masaaki Toda
- 申请人: Shuichi Ohuchida , Fumio Nambu , Masaaki Toda
- 申请人地址: JPX Osaka
- 专利权人: Ono Pharmaceuticals Co., Ltd.
- 当前专利权人: Ono Pharmaceuticals Co., Ltd.
- 当前专利权人地址: JPX Osaka
- 优先权: JPX5-231004 19930824
- 主分类号: C07D311/58
- IPC分类号: C07D311/58 ; C07D405/06 ; C07D521/00 ; A61K31/44
摘要:
Fused phenol derivatives of the formula (I): ##STR1## (wherein R.sup.1 and R.sup.2 each, independently, is H, halogen, trifluoromethyl, cyano, (substituted) alkyl, alkoxy, cycloalkyl, COOH, COOR.sup.6 (in which R.sup.6 is C1-6 alkyl), alkenyl or R.sup.1 and R.sup.2, taken together, is --CH.dbd.CH--CH.dbd.CH--, when R.sup.1 and R.sup.2 are ortho to each other; A is alkylene, alkenylene, oxyalkylene or ##STR2## (in which m is 1-6); B is a monocyclic hetero ring containing a nitrogen atom; G is --OR.sup.3A or --NR.sup.3B R.sup.3C (in which R.sup.3A, R.sup.3B and R.sup.3C each, independently, is H, alkyl, acyl, or alkoxyalkyl); R.sup.4 and R.sup.5 each, independently, is H, alkyl, or R.sup.4, R.sup.5 together with the carbon atom to which they are attached represent C4-7 cycloalkyl; and n is 1-3; non-toxic salts thereof, non-toxic acid addition salts thereof, and hydrates thereof. The compounds of the formula (I) have inhibitory activities on TXA.sub.2 synthetase and on 5-lipoxygenase and/or a scavenging activity on active oxygen species, and are useful for the prevention and/or the treatment of thrombosis, arteriosclerosis, ischemic heart diseases or brain diseases, bronchial asthma, renal inflammation, rheumatism, arthritis, gout, psoriasis, ulcerative colitis, trichophytosis, cardiac infarction, allergic diseases, etc.
公开/授权文献
- US4762930A Process for the preparation of the aluminum salt of saccharin 公开/授权日:1988-08-09
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