发明授权
- 专利标题： Peptide inhibitors of cellular adhesion
- 专利标题（中）： 肽抑制剂的细胞粘附
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申请号： US397101申请日： 1995-03-07
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公开(公告)号： US5753617A公开(公告)日： 1998-05-19
- 发明人: George A. Heavner , Marian Kruszynski , Margaret L. Falcone
- 申请人： George A. Heavner , Marian Kruszynski , Margaret L. Falcone
- 申请人地址： PA Malvern
- 专利权人： Centocor, Inc.
- 当前专利权人： Centocor, Inc.
- 当前专利权人地址： PA Malvern
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61P7/02 ; A61P9/00 ; A61P9/10 ; A61P11/00 ; A61P29/00 ; A61P35/00 ; A61P43/00 ; C07K7/06 ; C07K7/64 ; C07K14/705 ; A61K38/04 ; A61K38/12 ; C07K7/00
摘要：
Novel cyclic peptides of the selectin 54-63 sequence exhibit unexpected and desired properties. Specific points of cyclization or conformational restriction in conjunction with specific substitutions have been identified that not only unexpectedly enhance the biological activity of these compounds, but also significantly increase their resistance to enzymatic degradation. Formulae of the active compounds and representative examples of preferred peptides are presented herein.
公开/授权文献
- US6159113A Baseball strike indicator 公开/授权日：2000-12-12
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