A shaped catheter for accessing and treating preselected surfaces of cavities and organs within the human body, the apparatus including a tubular, shaped outer sheath with at least one guide hole and a tubular, flexible inner sleeve with a distal opening disposed adjacent the distal end, the inner sleeve slidably disposed within the outer sheath such that the distal opening of the inner sleeve can be operatively positioned adjacent the at least one of the guide holes and a laser delivery device or other functional device can be extended through the distal opening of the inner sleeve and through the guide hole on the outer sheath into the body cavity or organ. Providing a plurality of guide holes on the outer sheath will allow sequential treatment of the preselected surface within the body cavity or organ. Multiple TMR channels can be created or treatment at a number of sites can be made without moving or otherwise repositioning the outer sheath. The invention is also a method of use of such apparatus.