发明授权
US5756535A Substituted thiophenylalkenylcarboxylic acid guanidines, processes for
their preparation, their use as a medicament or diagnositc, and a
medicament containing them
失效
取代的噻吩基烯基羧酸胍,其制备方法,它们作为药物或诊断剂的用途,以及含有它们的药物
- 专利标题: Substituted thiophenylalkenylcarboxylic acid guanidines, processes for their preparation, their use as a medicament or diagnositc, and a medicament containing them
- 专利标题(中): 取代的噻吩基烯基羧酸胍,其制备方法,它们作为药物或诊断剂的用途,以及含有它们的药物
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申请号: US798259申请日: 1997-02-11
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公开(公告)号: US5756535A公开(公告)日: 1998-05-26
- 发明人: Jan-Robert Schwark , Joachim Brendel , Heinz-Werner Kleemann , Hans Jochen Lang , Andreas Weichert , Udo Albus , Wolfgang Scholz
- 申请人: Jan-Robert Schwark , Joachim Brendel , Heinz-Werner Kleemann , Hans Jochen Lang , Andreas Weichert , Udo Albus , Wolfgang Scholz
- 申请人地址: DEX Frankfurt am Main
- 专利权人: Hoechst Aktiengesellschaft
- 当前专利权人: Hoechst Aktiengesellschaft
- 当前专利权人地址: DEX Frankfurt am Main
- 优先权: DEX19605610.1 19960215
- 主分类号: C07D333/24
- IPC分类号: C07D333/24 ; A61K31/38 ; A61K31/381 ; A61P9/00 ; A61P9/06 ; A61P9/08 ; A61P9/10 ; A61P35/00 ; A61P43/00 ; C07C279/22 ; C07D333/02 ; C07D333/34 ; C07D333/32
摘要:
Substituted thiophenylalkenylcarboxylic acid guanidides, processes for their preparation, their use as a medicament or diagnostic, and a medicament containing them. There are described substituted thiophenylalkenylcarboxylic acid guanidides of the formula I ##STR1## in which R(1) to R(5) have the meanings given in the claims, which are outstandingly active antiarrhythmic pharmaceuticals having a cardioprotective component and are outstandingly suitable for infarct prophylaxis and infarct treatment and also for the treatment of angina pectoris, where they also inhibit or greatly reduce the pathophysiological processes in the formation of ischemically induced damage, in particular in the initiation of ischemically induced cardiac arrhythmias, in a preventive manner.
公开/授权文献
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