发明授权
US5756811A Process for the preparation of o-chloromethyl-phenylglyoxylic acid
derivatives
失效
制备邻氯甲基 - 苯基乙醛酸衍生物的方法
- 专利标题: Process for the preparation of o-chloromethyl-phenylglyoxylic acid derivatives
- 专利标题(中): 制备邻氯甲基 - 苯基乙醛酸衍生物的方法
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申请号: US774470申请日: 1996-12-30
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公开(公告)号: US5756811A公开(公告)日: 1998-05-26
- 发明人: Jean-Marie Assercq , Hans-Dieter Schneider , Albert Pfiffner , Werner Pfaff
- 申请人: Jean-Marie Assercq , Hans-Dieter Schneider , Albert Pfiffner , Werner Pfaff
- 申请人地址: NJ Summit
- 专利权人: Novartis Corporation
- 当前专利权人: Novartis Corporation
- 当前专利权人地址: NJ Summit
- 优先权: CHX1/96 19960103; CHX1112/96 19960502; CHX1874/96 19960726
- 主分类号: C07C229/40
- IPC分类号: C07C229/40 ; C07C69/716 ; C07C69/738 ; C07C69/76 ; C07C229/34 ; C07C229/36 ; C07C249/08 ; C07C251/48 ; C07C251/52 ; C07C251/58 ; C07C251/60 ; C07D295/155 ; C07C229/30
摘要:
There is described a process for the preparation of a compound of formula I ##STR1## in which process: a) a compound of formula II ##STR2## is reacted with an organolithium compound of formula III Li--R.sub.7 (III) b) the resulting lithium complex is reacted with a compound of formula IV Y.sub.1 --CO--CO--Y.sub.1 IV to form a compound of formula V ##STR3## c) that compound is, in either order, c1) oximated with O-methylhydroxylamine; or oximated with hydroxylamine and then methylated or fluoromethylated or difluoromethylated; c2) reacted with a chloroformic acid ester. X, m, Y, R.sub.1 to R.sub.3 and R.sub.7 are as defined in the description.
公开/授权文献
- US4695572A Isoindolinone derivatives, production and use thereof 公开/授权日:1987-09-22
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