发明授权
- 专利标题： Synthesis of intermediates useful in preparing bromo-substituted tricyclic compounds
- 专利标题（中）： 可用于制备溴代三环化合物的中间体的合成
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申请号： US882753申请日： 1997-06-16
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公开(公告)号： US5760232A公开(公告)日： 1998-06-02
- 发明人: Xing Chen , Marc Poirier , Yee-Shing Wong , Guang-Zhong Wu
- 申请人： Xing Chen , Marc Poirier , Yee-Shing Wong , Guang-Zhong Wu
- 申请人地址： NJ Kenilworth
- 专利权人： Schering Corporation
- 当前专利权人： Schering Corporation
- 当前专利权人地址： NJ Kenilworth
- 主分类号： C07D401/04
- IPC分类号： C07D401/04 ; C07D221/16
摘要：
The invention relates to a process for preparing a compound of the formula ##STR1## comprising: (a) reacting 2,5-dibromo-3-methylpyridine with an amine of the formula NHR.sup.5 R.sup.6 to obtain an amide; (b) reacting the amide with a compound of formula 3 ##STR2## in the presence of a strong base to obtain a compound of formula 4 ##STR3## (c) converting a compound of formula 4 to the corresponding cyano compound or aldehyde; (d) reacting the cyano compound or aldehyde with a piperidine derivative to obtain an aldehyde or alcohol of formula 7a or 7b, respectively: ##STR4## (e) cyclizing a compound of formula 7a or 7b; wherein R.sup.1 -R.sup.7 are as defined in the specification.