- 专利标题： Inhibitors of farnesyl-protein transferase
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申请号： US826317申请日： 1997-03-27
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公开(公告)号： US5780492A公开(公告)日： 1998-07-14
- 发明人: Christopher J. Dinsmore , Theresa M. Williams
- 申请人： Christopher J. Dinsmore , Theresa M. Williams
- 申请人地址： NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： NJ Rahway
- 主分类号： A61K31/4178
- IPC分类号： A61K31/4178 ; C07D233/54 ; A61K31/415 ; C07D233/61 ; C07D403/02 ; C07D403/06 ; C07D403/08 ; C07D403/10
摘要：
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
公开/授权文献
- US4681936A Preparation of sugar ketals 公开/授权日：1987-07-21
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