发明授权
US5786344A Camptothecin drug combinations and methods with reduced side effects
失效
喜树碱药物的组合和方法具有减少的副作用
- 专利标题： Camptothecin drug combinations and methods with reduced side effects
- 专利标题（中）： 喜树碱药物的组合和方法具有减少的副作用
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申请号： US423641申请日： 1995-04-17
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公开(公告)号： US5786344A公开(公告)日： 1998-07-28
- 发明人: Mark J. Ratain , Elora Gupta
- 申请人： Mark J. Ratain , Elora Gupta
- 申请人地址： IL Chicago
- 专利权人： Arch Development Corporation
- 当前专利权人： Arch Development Corporation
- 当前专利权人地址： IL Chicago
- 主分类号： A61K45/00
- IPC分类号： A61K45/00 ; A61K31/47 ; A61K45/06 ; A61K31/545
摘要：
This invention provides methods and combination formulations and kits to reduce the toxicity of camptothecin drugs, such as irinotecan (CPT-11). Disclosed are therapeutics and treatment methods employing such drugs in combination with agents that increase conjugative enzyme activity or glucuronosyltransferase activity, and agents that decrease biliary transport protein activity, such as cyclosporine A, the resultant effects of which are to decrease the significant side effects previously associated with treatment using these drugs.
公开/授权文献
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