Invention Grant
US5786348A Methods for preparation and use of 1.alpha.,24(S)-dihydroxy vitamin D.sub.2
失效
使用1α，24（S） - 二羟基维生素D2的方法
- Patent Title: Methods for preparation and use of 1.alpha.,24(S)-dihydroxy vitamin D.sub.2
- Patent Title (中): 使用1α，24（S） - 二羟基维生素D2的方法
-
Application No.: US477930Application Date: 1995-06-07
-
Publication No.: US5786348APublication Date: 1998-07-28
- Inventor: Charles W. Bishop , Ronald L. Horst , Glenville Jones , Nicholas J. Koszewski , Joyce C. Knutson , Robert M. Moriarty , Timothy A. Reinhardt , Raju Penmasta , Stephen Strugnell , Liang Guo , Sanjay K. Singhal , Lei Zhao
- Applicant: Charles W. Bishop , Ronald L. Horst , Glenville Jones , Nicholas J. Koszewski , Joyce C. Knutson , Robert M. Moriarty , Timothy A. Reinhardt , Raju Penmasta , Stephen Strugnell , Liang Guo , Sanjay K. Singhal , Lei Zhao
- Applicant Address: WI Madison
- Assignee: Bone Care International, Inc.
- Current Assignee: Bone Care International, Inc.
- Current Assignee Address: WI Madison
- Main IPC: A61K31/59
- IPC: A61K31/59 ; A61K45/06 ; C07C401/00 ; C07J9/00 ; C07J71/00
Abstract:
1.alpha.,24(S)-Dihydroxy vitamin D.sub.2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1.alpha.,24(S)-dihydroxy vitamin D.sub.2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D.sub.2 which is converted in six steps to 1.alpha.,24(S)-dihydroxy vitamin D.sub.2. The syntheses also produced novel intermediates.
Public/Granted literature
- US5113574A Process and device for the connection of armature coil wires with the lamellas of a hook-collecting device Public/Granted day:1992-05-19
Information query
