发明授权
- 专利标题: Fibrinogen receptor antagonists
- 专利标题(中): 纤维蛋白原受体拮抗剂
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申请号: US416772申请日: 1995-05-31
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公开(公告)号: US5786373A公开(公告)日: 1998-07-28
- 发明人: George D. Hartman , John D. Prugh , Melissa S. Egbertson , Mark E. Duggan , William Hoffman
- 申请人: George D. Hartman , John D. Prugh , Melissa S. Egbertson , Mark E. Duggan , William Hoffman
- 申请人地址: NJ Rahway
- 专利权人: Merck & Co., Inc.
- 当前专利权人: Merck & Co., Inc.
- 当前专利权人地址: NJ Rahway
- 主分类号: A61K31/38
- IPC分类号: A61K31/38 ; A61K31/381 ; A61K31/4427 ; A61K31/4433 ; A61K31/445 ; A61K31/454 ; A61P7/02 ; C07C311/06 ; C07C311/19 ; C07D233/64 ; C07D333/38 ; C07D401/12 ; C07D409/06 ; C07D409/12 ; C07D413/12 ; A61K31/415 ; A61K31/44 ; C07D333/22
摘要:
Novel fibrinogen receptor antagonists of the formula: X--Y--Z-Aryl-A--B and the pharmaceutically acceptable salts thereof, wherein Aryl is a 5-membered aromatic ring system containing 1 or 2 heteroatoms chosen from N, O or S wherein ring atoms may be unsubstituted or substituted with R.sup.5 and wherein S may be substituted with 0, 1 or 2 oxygen atoms; and X comprises various Nitrogen substituents including aromatic or nonaromatic systems; Y comprises, for example, alkyl or alkylaminocarbonylalkyl groups and Z and A are substituents which when present are independently chosen from alkyl or alkyloxyalkyl or other groups as defined herein; B is (a) or (b). The claimed compounds exhibit fibrinogen receptor antagonist activity, inhibit platelet aggregation and are therefore useful in modulating or preventing thrombus formation.