- 专利标题： Transformations of taxol
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申请号： US626112申请日： 1996-04-01
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公开(公告)号： US5786489A公开(公告)日： 1998-07-28
- 发明人: Kyriacos C. Nicolaou , Philippe G. Nantermet , Rodney K. Guy , Hiroaki Ueno
- 申请人： Kyriacos C. Nicolaou , Philippe G. Nantermet , Rodney K. Guy , Hiroaki Ueno
- 申请人地址： CA La Jolla
- 专利权人： The Scripps Research Institute
- 当前专利权人： The Scripps Research Institute
- 当前专利权人地址： CA La Jolla
- 主分类号： C07D305/14
- IPC分类号： C07D305/14 ; C07D493/08 ; C07D317/70
摘要：
A method for esterifying C13 deoxy taxoid intermediates employs three steps, i.e., oxygenation of the C13 deoxy taxoid intermediate to produce a C13 enone taxoid intermediate; reduction of the C13 enone to produce an alcohol; followed by esterification of the C13 alcohol. Key intermediates include C13 deoxy taxoids; C13 enone substituted taxoids; and C1-C2 cyclo carbonate esters of taxoids.