发明授权
- 专利标题: Guanidino protease inhibitors
- 专利标题(中): 胍基蛋白酶抑制剂
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申请号: US698401申请日: 1996-08-15
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公开(公告)号: US5792769A公开(公告)日: 1998-08-11
- 发明人: Tianbao Lu , Carl R. Illig , Bruce E. Tomczuk , Richard M. Soll , Nalin L. Subasinghe , Roger F. Bone
- 申请人: Tianbao Lu , Carl R. Illig , Bruce E. Tomczuk , Richard M. Soll , Nalin L. Subasinghe , Roger F. Bone
- 申请人地址: PA Exton
- 专利权人: 3-Dimensional Pharmaceuticals, Inc.
- 当前专利权人: 3-Dimensional Pharmaceuticals, Inc.
- 当前专利权人地址: PA Exton
- 主分类号: C07C279/04
- IPC分类号: C07C279/04 ; C07C279/12 ; C07C309/73 ; C07C311/21 ; C07D211/22 ; C07D295/215 ; A61K31/445 ; C07C279/00 ; C07D241/04 ; C07F9/06
摘要:
Compounds of the formula: ##STR1## wherein R.sup.1 --R.sup.4, R.sup.7 --R.sup.8, R.sup.a, R.sup.b, R.sup.c, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit a number of proteolytic enzymes are described. Also described are methods for preparing the compounds of Formula I.