利索-全球专利检索

  1. 登录
  2. 注册
发明授权
US5798092A Derivatized DTPA complexes pharmaceutical agents containing these compounds, their use, and processes for their production 失效
衍生的DTPA复合物含有这些化合物的药剂，它们的用途及其生产方法

Derivatized DTPA complexes pharmaceutical agents containing these compounds, their use, and processes for their production
摘要：
Compounds of general Formula I ##STR1## wherein Z.sup.1 and Z.sup.2 in each case independently mean the residue --(CH.sub.2).sub.m --(C.sub.6 H.sub.4).sub.q --(O).sub.k --(CH.sub.2).sub.n --(C.sub.6 H.sub.4).sub.l --(O).sub.r --R, wherein m and n means the numbers 0-20, k, l, q and r means the numbers 0 and 1, and R means a hydrogen atom, an optionally OR.sup.1 -substituted C.sub.1 -C.sub.6 -alkyl residue, or a CH.sub.2 COOR.sup.1 group with R.sup.1 meaning a hydrogen atom, a C.sub.1 -C.sub.6 -alkyl residue, or a benzyl group, with the proviso that at least two substituents X stand for a metal ion equivalent; that one of the substituents Z.sup.1 and Z.sup.2 stands for a hydrogen and the other is not H; that--if n and l each means the number 0--k and r do not simultaneously mean the number 1; that --(O).sub.r --R is not --OH; and that Z.sup.1 and Z.sup.2 are not --CH.sub.2 --C.sub.6 H.sub.4 --O--CH.sub.2 --COOCH.sub.2 C.sub.6 H.sub.5 or --CH.sub.2 --C.sub.6 H.sub.4 --O--(CH.sub.2).sub.5 --COOCH.sub.2 C.sub.6 H.sub.5, are valuable pharmaceutical agents, e.g., for NMR or X-ray imaging.
摘要（中）：

（I）的化合物，其中Z 1和Z 2在每种情况下独立地表示残基 - （CH 2）m - （C 6 H 4）q - （O）k - （CH 2）n - （C 6 H 4） ）rR，其中m和n表示数字0-20，k，l，q和r表示数字0和1，R表示氢原子，任选OR 1取代的C 1 -C 6烷基残基或CH 2 COOR 1 基团，其中R1表示氢原子，C1-C6烷基残基或苄基，条件是至少两个取代基X代表金属离子当量; 取代基Z1和Z2之一代表氢，而另一个不是H; 如果n和l每个意味着数字0-k和r不同时表示数字1; - （O）r-R不是-OH; Z1和Z2不是-CH2-C6H4-O-CH2-COOCH2C6H5或-CH2-C6H4-O-（CH2）5-COOCH2C6H5）是有价值的药剂，例如用于NMR或X射线成像。

公开/授权文献
信息查询
Global Dossier Espacenet
0/0