发明授权
US5798368A Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and
method of reducing TNF.alpha. levels
失效
四取代的2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉和降低TNFα水平的方法
- 专利标题: Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNF.alpha. levels
- 专利标题(中): 四取代的2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉和降低TNFα水平的方法
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申请号: US701494申请日: 1996-08-22
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公开(公告)号: US5798368A公开(公告)日: 1998-08-25
- 发明人: George W. Muller , David I. Stirling , Roger Shen-Chu Chen
- 申请人: George W. Muller , David I. Stirling , Roger Shen-Chu Chen
- 申请人地址: NJ Warren
- 专利权人: Celgene Corporation
- 当前专利权人: Celgene Corporation
- 当前专利权人地址: NJ Warren
- 主分类号: C07D401/04
- IPC分类号: C07D401/04 ; A61K31/44
摘要:
Tetrasubstituted 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines reduce the levels of TNF.alpha. in a mammal. A typical embodiment is 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4,5,6,7-tetrafluoroisoindoline.
公开/授权文献
- US4655639A Plough 公开/授权日:1987-04-07
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