An infusion device for use in delivering an infusate from an elongated infusion segment along an elongated section of a body vessel with either a relatively symmetric infusate distribution profile or asymmetric infusate distribution profile that concentrates infusate delivery proximally or distally along the infusion segment. The infusion segment is formed with an infusate distribution manifold for delivering infusate through a plurality of side wall exit ports in the elongated infusion segment having proximal and distal manifold end openings to which infusate is delivered in equal amounts to effect the relatively uniform infusate distribution profile or in relative proportions to effect the asymmetric infusate distribution profile. In differing embodiments, the infusate delivery is either fixed or may be adjusted by a proximal adjustable valve mechanism. The infusate is delivered through separate first and second infusion lumens to the distal and proximal manifold end openings, respectively, which preferably comprise inner and annular lumens formed by inner and outer coaxial tubes such that the distal section of the annular lumen forms the manifold.