An airplane fuselage including a plurality of individual subassemblies having components that are aligned using coordination holes. The components include an assembly of panels, a plurality of stringer clips, a plurality of frame members, shear ties, and a floor grid made of a plurality of crossmembers. The coordination holes are drilled in selected components and are located at positions on the subassemblies to accurately align the subassemblies relative to each other so the spatial relationship between key features of the subassemblies make them self-locating and intrinsically determinant of the final contour and configuration of the airplane fuselage, independent of hard tooling.