发明授权
US5824674A Brefeldin A derivatives and their utility in the treatment of cancer
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Brefeldin A衍生物及其在治疗癌症中的应用
- 专利标题： Brefeldin A derivatives and their utility in the treatment of cancer
- 专利标题（中）： Brefeldin A衍生物及其在治疗癌症中的应用
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申请号： US974902申请日： 1997-11-20
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公开(公告)号： US5824674A公开(公告)日： 1998-10-20
- 发明人: Louis Malspeis , B. Rao Vishnuvajjala , Jeffrey G. Supko , Charles Theodore Kane, Jr.
- 申请人： Louis Malspeis , B. Rao Vishnuvajjala , Jeffrey G. Supko , Charles Theodore Kane, Jr.
- 申请人地址： DC Washington NY Buffalo
- 专利权人： The United States of America as represented by the Department of Health and Human Services,Starks Associates
- 当前专利权人： The United States of America as represented by the Department of Health and Human Services,Starks Associates
- 当前专利权人地址： DC Washington NY Buffalo
- 主分类号： A61K31/365
- IPC分类号： A61K31/365 ; A61P35/02 ; C07D313/00 ; A61K31/55
摘要：
Provided are brefeldin A derivatives of the formula: ##STR1## wherein one of R.sub.1 and R.sub.2 is H and the other of R.sub.1 and R.sub.2 is a substituent group having 1 to 12 carbon atoms containing a basic nitrogen atom or a quaternary ammonium group, or a salt thereof. These derivatives exhibit good antitumor activity, and are administrable to human patients without the problems associated with brefeldin A.
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