发明授权
US5834199A Methods of identifying transition metal complexes that selectively
cleave regulatory elements of mRNA and uses thereof
失效
识别选择性切割mRNA调节元件的过渡金属配合物的方法及其用途
- 专利标题： Methods of identifying transition metal complexes that selectively cleave regulatory elements of mRNA and uses thereof
- 专利标题（中）： 识别选择性切割mRNA调节元件的过渡金属配合物的方法及其用途
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申请号： US841166申请日： 1997-04-29
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公开(公告)号： US5834199A公开(公告)日： 1998-11-10
- 发明人: Elizabeth C. Theil
- 申请人： Elizabeth C. Theil
- 申请人地址： NC Raleigh
- 专利权人： North Carolina State University
- 当前专利权人： North Carolina State University
- 当前专利权人地址： NC Raleigh
- 主分类号： C12N15/67
- IPC分类号： C12N15/67 ; C12Q1/68
摘要：
Methods for selecting transition metal complexes (TMCs) that can modulate the translation of an mRNA by selectively cleaving a regulatory element of the mRNA are described. Included are in vitro, in situ, and/or in vivo methods. In addition, methods of identifying and characterizing mRNAs that contain regulatory elements which can be targeted by the TMCs of the present invention are also provided. Pharmaceutical compositions containing the TMCs of the present invention are also included.