发明授权
- 专利标题： Method for inhibiting thrombosis in a patient whose blood is subjected to extracorporeal circulation
- 专利标题（中）： 血液经受体外循环的患者血栓形成抑制方法
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申请号： US648561申请日： 1996-05-16
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公开(公告)号： US5839443A公开(公告)日： 1998-11-24
- 发明人: Eric Rose , David Stern , Ann Marie Schmidt , Talia Spanier
- 申请人： Eric Rose , David Stern , Ann Marie Schmidt , Talia Spanier
- 申请人地址： NY New York
- 专利权人： The Trustees of Columbia University in the City of New York
- 当前专利权人： The Trustees of Columbia University in the City of New York
- 当前专利权人地址： NY New York
- 主分类号： A61K38/36
- IPC分类号： A61K38/36 ; A61K38/48 ; A61M1/36 ; G01N33/86 ; A61B19/00
摘要：
This invention provides an assay to monitor antithrombic activity of a Factor IXa compound infused into circulation of a patient which includes: (a) obtaining Factor IXa-deficient plasma; (b) mixing the plasma from step (a) with diatomaceous and with plasma from the patient; (c) incubating the mixture with a source of lipid and calcium chloride under conditions suitable for clot formation; and (d) measuring time necessary for clot formation in the incubate, thereby monitoring the antithrombic activity of the Factor IXa compound infused into the circulation of the patient.
公开/授权文献
- US4023808A Resilient force resistor type exercising device 公开/授权日：1977-05-17
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