发明授权
- 专利标题: Pyrazole derivatives
- 专利标题(中): 吡唑衍生物
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申请号: US998669申请日: 1997-12-29
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公开(公告)号: US5840909A公开(公告)日: 1998-11-24
- 发明人: Keizo Tanikawa , Yoshimasa Kamikawaji , Keisuke Odoi , Tsutomu Higashiyama , Masayuki Sato , Yukinori Masuda
- 申请人: Keizo Tanikawa , Yoshimasa Kamikawaji , Keisuke Odoi , Tsutomu Higashiyama , Masayuki Sato , Yukinori Masuda
- 申请人地址: JPX Tokyo
- 专利权人: Nissan Chemical Industries, Ltd.
- 当前专利权人: Nissan Chemical Industries, Ltd.
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX5-80922 19930407; JPX6-917 19940110
- 主分类号: C07D231/38
- IPC分类号: C07D231/38 ; C07D401/14 ; C07D403/12 ; C07D403/14 ; C07D405/12 ; C07D405/14 ; C07D409/12 ; C07D409/14 ; C07F9/6558 ; A61K31/415
摘要:
Pyrazole compounds of formula �1! and their tautomers and salts: ##STR1## (wherein R.sup.1 is an alkyl group, etc.; R.sup.2 is a carboxyl group, etc.; R.sup.3 is a halogen atom, an alkyl group, a phenyl group, etc.; R.sup.4, R.sup.5 and R.sup.6 each are a hydrogen atom, a halogen atom, etc.; R.sup.7 is a carboxyl group, a 5-tetrazolyl group, etc.; X is a nitrogen atom, etc.; Y and Z each are CH, a nitrogen atom, etc.; A and E each are a methylene group, etc.; D is a phenyl group, etc.; G is a covalent bond, etc.). The compounds of the invention have an antagonistic effect against angiotensin II and are useful for prevention and remedy of hypertension, congestive cardiac insufficiency, chronic renal insufficiency, aldosteronism, hyper-intraocular pressure, etc.
公开/授权文献
- US5275198A Portable self-contained ground water testing assembly 公开/授权日:1994-01-04
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