- 专利标题: Therapeutic phenoxyalkylazoles and phenoxyalkylazines
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申请号: US978233申请日: 1997-11-25
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公开(公告)号: US5846986A公开(公告)日: 1998-12-08
- 发明人: David J. Aldous , Thomas R. Bailey , Guy Dominic Diana , Theodore J. Nitz , Gee-Hong Kuo
- 申请人: David J. Aldous , Thomas R. Bailey , Guy Dominic Diana , Theodore J. Nitz , Gee-Hong Kuo
- 申请人地址: FRX
- 专利权人: Sanofi
- 当前专利权人: Sanofi
- 当前专利权人地址: FRX
- 主分类号: C07D257/04
- IPC分类号: C07D257/04 ; C07D271/06 ; C07D277/24 ; C07D403/12 ; C07D405/12 ; C07D413/12 ; C07D417/12 ; C07D521/00 ; A61K31/41
摘要:
Compounds of the formula ##STR1## wherein Azo is alkyltetrazolyl or is chosen from the group consisting of oxadiazolyl, imidazolyl, pyrazolyl, triazolyl, oxazolyl, triazinyl, thiazolyl, isothiazolyl or any of these substituted with a member of the group consisting of alkyl, alkylthio, alkoxy, hydroxy, halo, cyano, nitro, hydroxyalkyl, alkoxyalkyl, alkoxycarbonyl, alkanoyl, fluoroalkyl or the N-oxide of any of the preceding; Y is an alkylene bridge of 3-9 carbon atoms; R.sub.1 and R.sub.2 are each individually chosen from hydrogen, halo, alkyl, alkenyl, amino, alkylthio, hydroxy, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, alkoxy, nitro, carboxy, alkoxycarbonyl, dialkylaminoalkyl, alkylaminoalkyl, aminoalkyl, difluoromethyl, trifluoromethyl or cyano; R.sub.3 is alkoxycarbonyl, alkyltetrazolyl, phenyl or a heterocycle chosen from benzoxazolyl, benzathiazolyl, thiadiazolyl, imidazolyl, dihydroimidazolyl, oxazolyl, thiazolyl, oxadiazolyl, pyrazolyl, isoxazolyl, isothiazolyl, furyl, triazolyl, tetrazolyl, thiophenyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl or substituted phenylor substituted heterocyclyl wherein the substitution is with alkyl, alkoxyalkyl, cycloalkyl, haloalkyl, hydroxyalkyl, alkoxy, hydroxy, furyl, thienyl or fluoroalkyl; the N-oxide thereof; or a pharmaceutically acceptable acid addition salt thereof is an effective antipicornaviral agents.
公开/授权文献
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