发明授权
US5852183A Dog-mouse heterohybridoma and gene fragment coding for constant region
of canine immunoglobulins
失效
犬小鼠异源杂交瘤和编码犬免疫球蛋白恒定区的基因片段
- 专利标题: Dog-mouse heterohybridoma and gene fragment coding for constant region of canine immunoglobulins
- 专利标题(中): 犬小鼠异源杂交瘤和编码犬免疫球蛋白恒定区的基因片段
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申请号: US646981申请日: 1996-05-08
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公开(公告)号: US5852183A公开(公告)日: 1998-12-22
- 发明人: Hiroaki Maeda , Yasuyuki Eda , Kazuhiko Kimachi , Yoichi Ono , Sachio Tokiyoshi
- 申请人: Hiroaki Maeda , Yasuyuki Eda , Kazuhiko Kimachi , Yoichi Ono , Sachio Tokiyoshi
- 申请人地址: JPX Kumamoto-ken
- 专利权人: Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
- 当前专利权人: Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
- 当前专利权人地址: JPX Kumamoto-ken
- 优先权: JPX1-219889 19890825; JPX1-255425 19890930; JPX2-150673 19900607
- 主分类号: A61K39/00
- IPC分类号: A61K39/00 ; C07K16/46 ; C12N5/26 ; C12N15/13 ; C07H2/04 ; C07H21/02
摘要:
A gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of canine immunoglobulin lambda chain; a gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of canine immunoglobulin kappa chain; a gene fragment which comprises a DNA sequence coding for the constant region of canine immunoglobulin gamma chain; a recombinant DNA molecule coding for an amino acid sequence of a mouse-dog chimeric antibody which comprises a gene fragment coding for an amino acid sequence of a variable region of a mouse immunoglobulin and a gene fragment coding for an amino acid sequence of a constant region of a canine immunoglobulin wherein the latter gene fragment; a polypeptide of a mouse-dog chimeric antibody which is expressed from a cell transformed with an expression vector for cells wherein said recombinant DNA molecule cording for an amino acid sequence of the mouse-dog chimeric antibody is incorporated; a dog-mouse heterohybridoma which produces canine immunoglobulin; and a process for preparing a canine immunoglobulin gene.
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