发明授权
US5855902A Method of administering a vaccine comprising tritrichomonas foetus
membrane surface antigens between 45 and 300 kilopaltons
失效
施用包含45-300千道尔顿的胎儿膜表面抗原的三氯胞嘧啶的疫苗的方法
- 专利标题: Method of administering a vaccine comprising tritrichomonas foetus membrane surface antigens between 45 and 300 kilopaltons
- 专利标题(中): 施用包含45-300千道尔顿的胎儿膜表面抗原的三氯胞嘧啶的疫苗的方法
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申请号: US192807申请日: 1994-02-07
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公开(公告)号: US5855902A公开(公告)日: 1999-01-05
- 发明人: Miodrag Ristic , Lionel Wanduragala
- 申请人: Miodrag Ristic , Lionel Wanduragala
- 申请人地址: MN St. Paul
- 专利权人: Protatek International, Inc.
- 当前专利权人: Protatek International, Inc.
- 当前专利权人地址: MN St. Paul
- 主分类号: A61K39/002
- IPC分类号: A61K39/002 ; A23J3/20 ; C07K14/44
摘要:
A subunit vaccine for Tritrichomonas foetus and method for preparing such vaccine for use in immunizing and treating animals is provided. The method disclosed involves separating out the antigens by centrifuging homogenized Tritrichomonas foetus cells, preferably at about 830.times.g for about 15 minutes, solubilizing the antigen with an nonionic detergent and completing with saponin. Topical administration, such as intravaginal or intrapretutial administration, of such vaccine preparation in conjunction with subcutaneous administration in combination with other adjuvants is effective to eliminate infection.
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