发明授权
- 专利标题: Fatty acid analogs and prodrugs
- 专利标题(中): 脂肪酸类似物和前药
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申请号: US049237申请日: 1998-03-27
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公开(公告)号: US5859052A公开(公告)日: 1999-01-12
- 发明人: Sean T. Nugent , Richard A. Mueller
- 申请人: Sean T. Nugent , Richard A. Mueller
- 申请人地址: IL Chicago
- 专利权人: G. D. Searle & Co.
- 当前专利权人: G. D. Searle & Co.
- 当前专利权人地址: IL Chicago
- 主分类号: C07C45/00
- IPC分类号: C07C45/00 ; C07C59/135 ; C07C229/18 ; C07C235/06 ; C07C235/12 ; C07C235/16 ; C07C237/22 ; C07C255/13 ; C07C255/16 ; C07C271/22 ; C07D209/20 ; C07D257/04 ; A61K31/08 ; A61K31/22 ; C07C43/06 ; C07C229/08
摘要:
Novel derivatives of fatty acid analogs that have from one to three heteroatoms in the fatty acid moiety which can be oxygen, sulfur or nitrogen, are disclosed in which the carboxy-terminus has been modified to form various amides, esters, ketones, alcohols, alcohol esters and nitrites thereof.These compounds are useful as substrates for N-myristoyltransferase (NMT) and/or its acyl coenzyme, and as anti-viral and anti-fungal agents or pro-drugs of such agents. Illustrative of the disclosed compounds are fatty acid amino acid analogs of the structure ##STR1## in which x is the ethyl or t-butyl ester of an amino acid such as Gly, L-Ala, L-Ile, L-Phe, L-Trp, L-Thr or an amide such as NHCH.sub.2 C.sub.6 H.sub.5 or NH(CH.sub.2).sub.2 C.sub.6 H.sub.5.
公开/授权文献
- USD378067S Audible transmitter for locating missing objects 公开/授权日:1997-02-18