发明授权
US5859249A 2-phenyl-2-(2'-piperidinylidene)acetate derivative, process for
manufacturing the same, and process for manufacturing optically active
2-phenyl-2-(2'-piperidinyl)acetate derivative by asymmetrically
hydrogenating the same
失效
2-苯基-2-（2'-亚哌啶基）乙酸酯衍生物，其制备方法，以及通过不对称氢化其制备光学活性2-苯基-2-（2'-哌啶基）乙酸酯衍生物的方法
- 专利标题： 2-phenyl-2-(2'-piperidinylidene)acetate derivative, process for manufacturing the same, and process for manufacturing optically active 2-phenyl-2-(2'-piperidinyl)acetate derivative by asymmetrically hydrogenating the same
- 专利标题（中）： 2-苯基-2-（2'-亚哌啶基）乙酸酯衍生物，其制备方法，以及通过不对称氢化其制备光学活性2-苯基-2-（2'-哌啶基）乙酸酯衍生物的方法
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申请号： US895428申请日： 1997-07-16
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公开(公告)号： US5859249A公开(公告)日： 1999-01-12
- 发明人: Nobuo Seido , Takenobu Nishikawa , Tsukasa Sotoguchi , Yoshifumi Yuasa , Takashi Miura , Hidenori Kumobayashi
- 申请人： Nobuo Seido , Takenobu Nishikawa , Tsukasa Sotoguchi , Yoshifumi Yuasa , Takashi Miura , Hidenori Kumobayashi
- 申请人地址： JPX Tokyo
- 专利权人： Takasago International Corporation
- 当前专利权人： Takasago International Corporation
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX9-072570 19970219; JPX9-117358 19970402
- 主分类号： C07C229/34
- IPC分类号： C07C229/34 ; C07C271/22 ; C07D211/70 ; C07D211/02 ; C07D211/32
摘要：
Disclosed is a 2-phenyl-2-(2'-piperidinylidene)acetate derivative suitably used for a raw material of a 2-phenyl-2-(2'-piperidinyl)acetate derivative and a process for manufacturing the same. Also disclosed is a process for manufacturing an optically active 2-phenyl-2-(2'-piperidinyl)acetate derivative which is a major intermediate for an antidepressant. The 2-phenyl-2-(2'-piperidinylidene)acetate derivative is manufactured by cyclizing a 7-(N-substituted amino)-3-oxo-2-heptanoate derivative. The optically active 2-phenyl-2-(2'-piperidinyl)acetate derivative is manufactured by asymmetrically hydrogenating the 2-phenyl-2-(2'-piperidinylidene)acetate derivative in the presence of a complex of a Group VIII transition metal or an acid.
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