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发明授权
US5861429A 13-substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests 失效
13-取代的米尔倍霉素5-肟衍生物，它们的制备及其对昆虫和其它害虫的用途

13-substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests
摘要：
Compounds of formula (I): ##STR1## wherein: R.sup.1 is methyl, ethyl, isopropyl or sec-butyl; X is carbonyl or methylene; Z is .dbd.C.dbd.(R.sup.2).sub.2 or .dbd.C.dbd.(CH.sub.2).sub.m, in which R.sup.2 is alkyl, and m is integer of from 2 to 5); n is 0 or 1; R.sup.3 is nitro, amino, alkylamino, dialkylamino, alkoxy, alkoxyalkoxy, or a group (iii), (iv), (v), (vi), (vii), (viii) or (ix): ##STR2## , wherein: R.sup.4 represents: alkyl; substituted alkyl; cycloalkyl having from 3 to 6 carbon atoms; substituted cycloalkyl; alkenyl; alkynyl; carbocyclic aryl; or heterocyclic; R.sup.5 is hydrogen atom or alkyl; R.sup.6 represents: hydrogen; alkyl; or cycloalkyl; R.sup.7 represents: alkyl; cycloalkyl; carbocyclic aryl; or aralkyl; or R.sup.6 and R.sup.7, together with the nitrogen atom to which they are attached, are fuised to form heterocyclic ring; Y is oxygen or sulfur; r is 1, 2 or 3; Q is methylene or carbonyl; R.sup.8 is: alkyl or carbocyclic aryl; R.sup.9 is: alkyl; cycloalkyl; carbocyclic aryl; or aralkyl; R.sup.10 is heterocyclic; and R.sup.11 is aLkyl; have valuable acaricidal, insecticidal and anthelmintic activities.
摘要（中）：

式（I）的化合物：其中：R1是甲基，乙基，异丙基或仲丁基; X是羰基或亚甲基; Z为= C =（R2）2或= C =（CH2）m，其中R2为烷基，m为2至5的整数）; n为0或1; （iii），（iv），（v），（vi），（vii），（viii）或（ix）：（iii） （ix）ix;;;;;;;;;;;;;;;;：：：：：：：：：：：：：：：;;;;;;;;;;; 取代的烷基; 具有3至6个碳原子的环烷基; 取代的环烷基; 烯基; 炔基; 碳环芳基; 或杂环; R5是氢原子或烷基; R6表示：氢; 烷基; 或环烷基; R 7表示：烷基; 环烷基 碳环芳基; 或芳烷基; 或R6和R7与它们所连接的氮原子一起被引发形成杂环; Y是氧或硫; r为1,2或3; Q是亚甲基或羰基; R8是：烷基或碳环芳基; R9是：烷基; 环烷基 碳环芳基; 或芳烷基; R10是杂环的; R11为烷基; 具有有效的杀螨，杀虫和驱虫活动。

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