发明授权
- 专利标题: Amidinonaphthyl derivative or salt thereof
- 专利标题(中): 脒基萘基衍生物或其盐
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申请号: US849391申请日: 1997-05-30
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公开(公告)号: US5869501A公开(公告)日: 1999-02-09
- 发明人: Fukushi Hirayama , Hiroyuki Koshio , Yuzo Matsumoto , Tomihisa Kawasaki , Seiji Kaku , Isao Yanagisawa
- 申请人: Fukushi Hirayama , Hiroyuki Koshio , Yuzo Matsumoto , Tomihisa Kawasaki , Seiji Kaku , Isao Yanagisawa
- 申请人地址: JPX Tokyo
- 专利权人: Yamanouchi Pharmaceutical Co. Ltd
- 当前专利权人: Yamanouchi Pharmaceutical Co. Ltd
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX6-299963 19941202; JPX7-105205 19950428; JPX7-198816 19950803
- 主分类号: C07D211/44
- IPC分类号: C07D211/44 ; A61K31/445 ; A61P7/02 ; C07D211/46 ; C07D401/12 ; C07D409/12
摘要:
An amidinonaphthyl derivative represented by the following general formula (I) which has coagulation factor X inhibiting action and is useful as an anti-thrombus agent and the like, a salt thereof, an intermediate thereof and a pharmaceutical composition which comprises the amidinonaphthyl derivative. An amidinonaphthyl derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof. ##STR1## (symbols in the formula have the following meanings; R.sup.1 : a hydrogen atom or a group represented by the formula --A--W--R.sup.4,A: a group represented by the formula ##STR2## a group represented by the formula ##STR3## or a group represented by the formula --SO.sub.2 --, X: an oxygen atom or a sulfur atom, W: a single bond or a group represented by the formula --NR.sup.5 --, R.sup.4 : a hydroxyl group, a lower alkoxy group, etc., R.sup.5 : a hydrogen atom, a carbamoyl group, a lower alkoxycarbonyl group, etc., R.sup.2 : a lower alkyl group, R.sup.3 : a hydrogen atom, a halogen atom, a carboxyl group, B: a lower alkylene group or a carbonyl group, and n: 0 or 1).
公开/授权文献
- US5333628A Continuous ultrasonic cleaning apparatus 公开/授权日:1994-08-02