发明授权
- 专利标题： Screening assays for cancer chemopreventative agents
- 专利标题（中）： 癌症化学预防剂的筛选试验
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申请号： US896462申请日： 1997-07-18
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公开(公告)号： US5874235A公开(公告)日： 1999-02-23
- 发明人: Timothy A. Chan , Patrice J. Morin , Bert Vogelstein , Kenneth W. Kinzler
- 申请人： Timothy A. Chan , Patrice J. Morin , Bert Vogelstein , Kenneth W. Kinzler
- 专利权人： The Johns Hopkins University
- 当前专利权人： The Johns Hopkins University
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; C12Q1/34 ; C12Q1/00 ; C12Q1/42
摘要：
Nonsteroidal anti-inflammatory drugs cause a dramatic increase in intracellular ceramide, which induces apoptosis. The ceramide increase is likely mediated by cyclooxygenase inhibition, which elevates arachidonic acid, which stimulates sphingomyelinase, which produces ceramide. Contacting members of this pathway with test compounds and observing their effects provides a method of screening for potential cancer chemopreventative agents.
公开/授权文献
- US5187809A Dual mode automatic gain control 公开/授权日：1993-02-16
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