发明授权
US5886217A Method of producing aryl-substituted, amino-acylated phosphonic-acid
derivatives with the aid of metal complexes of chiral, amphiphilic
ligands
失效
借助手性，两亲性配体的金属络合物制备芳基取代的氨基酰化膦酸衍生物的方法
- 专利标题： Method of producing aryl-substituted, amino-acylated phosphonic-acid derivatives with the aid of metal complexes of chiral, amphiphilic ligands
- 专利标题（中）： 借助手性，两亲性配体的金属络合物制备芳基取代的氨基酰化膦酸衍生物的方法
-
申请号： US974802申请日： 1997-11-20
-
公开(公告)号： US5886217A公开(公告)日： 1999-03-23
- 发明人: Gunther Oehme , Ute Schmidt , Silke Ziegler , Ingrid Grassert , Christine Fischer
- 申请人： Gunther Oehme , Ute Schmidt , Silke Ziegler , Ingrid Grassert , Christine Fischer
- 申请人地址： DEX Frankfurt
- 专利权人： Degussa Aktiengesellschaft
- 当前专利权人： Degussa Aktiengesellschaft
- 当前专利权人地址： DEX Frankfurt
- 优先权： DEX19647885.5 19961120; DEX19730657.8 19970717
- 主分类号： B01J31/18
- IPC分类号： B01J31/18 ; B01J31/24 ; C07F9/38 ; C07F9/40 ; C07F9/58 ; C07F9/655 ; C07F9/6553 ; C07F9/22
摘要：
The invention is relates to a method of producing aryl-substituted, amino-acylated phosphonic-acid derivatives with the aid of metal complexes of chiral amphiphilic ligands in that according to the invention .alpha.-N-acyl-protected, .beta.-substituted alkene phosphone derivatives are asymmetrically hydrogenated in the presence of a chiral rhodium catalyst in a solvent or a suspension. The use of the micelle-forming catalyst makes possible the hydrogenation of unsaturated phosphonic-acid derivatives in water with a high reaction rate with the obtainment of very good enantiomeric excesses.
公开/授权文献
- US5293915A Manual milling machine 公开/授权日：1994-03-15
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