发明授权
- 专利标题： Method for stabilizing pranoprofen and stable liquid preparation of pranaprofen
- 专利标题（中）： 双吡苯丙酸稳定药液的稳定化方法
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申请号： US873924申请日： 1997-06-12
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公开(公告)号： US5889030A公开(公告)日： 1999-03-30
- 发明人: Koji Doi , Hisako Sawa , Yoshie Ozaki , Yoshiyuki Kimura
- 申请人： Koji Doi , Hisako Sawa , Yoshie Ozaki , Yoshiyuki Kimura
- 申请人地址： JPX Osaka JPX Osaka
- 专利权人： Senju Pharmaceutical Co., Ltd.,Yoshitomi Pharmaceutical Industries, Ltd.
- 当前专利权人： Senju Pharmaceutical Co., Ltd.,Yoshitomi Pharmaceutical Industries, Ltd.
- 当前专利权人地址： JPX Osaka JPX Osaka
- 主分类号： A61K31/436
- IPC分类号： A61K31/436 ; A61K9/00 ; A61K9/08 ; A61K31/435 ; A61K47/02 ; A61K47/08 ; A61K47/10 ; A61K47/16 ; A61K47/18 ; A61K47/22 ; A61P29/00 ; A61K31/44
摘要：
A method for stabilizing pranoprofen, comprising placing an aqueous solution of pranoprofen in coexistence with an antioxidant, or placing an aqueous solution of pranoprofen under the conditions of limited supply of oxygen, and a stable aqueous preparation of pranoprofen, comprising pranoprofen and an antioxidant. According to the present invention, the decomposition of pranoprofen in an aqueous solution of pranoprofen is remarkably suppressed. In particular, pranoprofen becomes stable to light, thus permitting long-term preservation of an aqueous solution, specifically a liquid preparation, of pranoprofen.
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